High-spirited Rachael Rothburn is eager to leave her luxurious life in Buffalo, New York, to share the gospel with Native Americans in the Oregon Territory. But the missionary alliance requires their missionaries to be married and Rachael has no husband or suitors. When Dr. Jonathan Wheaton, another missionary hopeful, learns about the restriction, he is desperate to find a wife. He offers Rachael a marriage of convenience and she agrees. After a hasty wedding, the pair sets off for the west knowing little about each other. Together they battle raging rivers, hostile Indians, sickness, treacherous mountain trails, and more. But as the seeds of love begin to grow, Jonathan's jealousy and pride threaten to be an even greater danger than anything they find in the west. Can they overcome the challenges and discover a true and lasting love?